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Titolo/Abstract/Parole chiave

Biomimetic Light-Driven E/Z Switcher: Design and Syntesis

Farina, Grazia (2011) Biomimetic Light-Driven E/Z Switcher: Design and Syntesis. Tesi di Dottorato , Università degli Studi di Ferrara.

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    Abstract

    This thesis examines the design and synthesis of a new class of biomimetic switches that replicate different aspect of the Z/E photoisomerization of rhodopsin. Theoretical studies on rhodopsin showed that a penta-2,4-dieniminium moiety is the minimal structure responsible of the photochemical properties of the visual pigment. By trapping this π system into conformational rigid molecules we synthesized NAIP (N-alkylated indanylidene-pyrroline Schiff base) switches featuring a selective and ultra-fast light-driven E/Z photoisomerization. Computational and spectroscopic studies performed on the particular NAIPzw, have shown it constitutes the prototype of a novel generation of electrostatic switches potentially capable to influence the conformational state of macromolecular structures (as a protein). Our efforts are now directed towards the functionalization of this kind of system to create the specific molecular linkages on NAIP structure so as to allow its insertion in a peptide domain.

    Tipologia del documento:Tesi di Dottorato (Tesi di Dottorato)
    Data:14 Marzo 2011
    Relatore:Zanirato, Vinicio
    Coordinatore ciclo:Manfredini, Stefano
    Istituzione:Università degli Studi di Ferrara
    Dottorato:XXIII Anno 2008 > SCIENZE FARMACEUTICHE
    Struttura:Dipartimento > Scienze farmaceutiche
    Soggetti:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
    Parole chiave:molecular switches
    Depositato il:13 Apr 2012 14:58

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