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Title/Abstract/Keywords

Basi genetiche dell’adattamento alle basse pressioni di ossigeno in popolazioni di alta quota delle Ande peruviane.

Chianella, Caterina (2011) Basi genetiche dell’adattamento alle basse pressioni di ossigeno in popolazioni di alta quota delle Ande peruviane. PhD Thesis , Università degli Studi di Ferrara.

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    Abstract

    High-altitude is the only environment colonized by modern humans where no behavioral buffering is available to face the peculiar and unavoidable stress: hypoxia. Life at low oxygen pressure needs specific biological adaptations to deliver enough oxygen to maintain aerobic metabolism. In the last decades many studies investigated the relationship between altitude and adaptive phenotypic traits, but to date no association between genetic variants and adaptive traits to hypoxia-related stress have been found in native American highlands. Here we aim at identifying the genetic bases of human adaptation to high altitude by studying the evolution of candidate genes and investigating their genetic variation in Andean native populations. The hypoxia inducible factors (HIF-1

    Item Type:Thesis (PhD Thesis)
    Date:11 March 2011
    Tutor:Fuselli, Silvia
    Coordinator:Barbujani, Guido
    Institution:Università degli Studi di Ferrara
    PhD:XXIII Anno 2008 > BIOLOGIA EVOLUZIONISTICA E AMBIENTALE
    Divisions:Dipartimento > Biologia ed evoluzione
    Subjects:Area 05 - Scienze biologiche > BIO/18 Genetica
    Uncontrolled Keywords:ipossia, hypoxia
    Deposited on:13 Apr 2012 14:57

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