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Title/Abstract/Keywords

EFFETTI DELLA STIMOLAZIONE MAGNETICA TRANSCRANICA RIPETITIVA (rTMS) A BASSA FREQUENZA DELLA CORTECCIA MOTORIA SULLA ECCITABILITÀ DEL BLINK REFLEX: STUDIO SPERIMENTALE SU SOGGETTI SANI

De Vito, Alessandro (2009) EFFETTI DELLA STIMOLAZIONE MAGNETICA TRANSCRANICA RIPETITIVA (rTMS) A BASSA FREQUENZA DELLA CORTECCIA MOTORIA SULLA ECCITABILITÀ DEL BLINK REFLEX: STUDIO SPERIMENTALE SU SOGGETTI SANI. PhD Thesis , Università degli studi di Ferrara.

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    Abstract

    Objective: To evaluate the after-effects of low frequency, sub-threshold repetitive Transcranial Magnetic Stimulation (rTMS) of primary motor cortex, on the excitability of Blink Reflex (BR) in healthy subjects. Methods: The BR recovery cycle was carried out in 10 healthy volunteers in basal conditions, immediately after rTMS (30 s), 15 and 60 min later. A paired electric supraorbital stimulus paradigm with inter-stimulus intervals (ISI) of 100–600–1000–1500 ms was used. The ‘‘real” rTMS consisted of a 200 stimuli long train delivered at 1 Hz and intensity 80% of rest Motor Threshold of the FDI muscle, using a focal coil applied over the primary motor cortex region. The basal BR recovery cycle was also compared with that obtained after a ‘‘sham” rTMS. Results: The recovery of the R2 component of the BR was significantly suppressed 30 s after rTMS. This effect was also observed at 15 min, though of lower magnitude and only at long ISIs (1000-1500 ms). No significant effect on R2 recovery was observed 60 min after real rTMS as well as after sham rTMS. Conclusions: Slow (1 Hz), sub-threshold rTMS of motor cortex can modulate the BR excitability determining a long-lasting inhibitory effect probably through its action on the cortical excitability and the cortico-bulbar facilitatory drive to the BR pathways.

    Item Type:Thesis (PhD Thesis)
    Date:5 March 2009
    Tutor:Granieri, Enrico
    Coordinator:Martini, Alessandro
    Institution:Università degli studi di Ferrara
    PhD:XXI Anno 2006 > SCIENZE BIOMEDICHE ENDOCRINOLOGICHE E NEUROFISIOLOGICHE
    Divisions:Dipartimento > Discipline medico-chirurgiche della comunicazione e del comportamento
    Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
    Uncontrolled Keywords:rTMS, Blink Reflex
    Deposited on:05 Jul 2009 08:22

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