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Title/Abstract/Keywords

NOVEL ANTITUMOR AGENTS STRUCTURALLY RELATED TO AMINOBISPHOSPHONATES AND STILBENES

Eleopra, Marco (2009) NOVEL ANTITUMOR AGENTS STRUCTURALLY RELATED TO AMINOBISPHOSPHONATES AND STILBENES. PhD Thesis , Università degli studi di Ferrara.

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    Abstract

    Cancer is one of the principal causes of death in the world and its therapy research leads a strong, but nowadays without great results, interest by scientific community. The treatment given for cancer is highly variable and dependent on a number of factors including the type, location and amount of disease and the health status of the patient (surgery, radiation, chemotherapy, hormonal treatment, antibodies, immunotherapy) but the discover of compounds able to kill selectively the affected cells is the main goal for medicinal chemists. With the aim to decrease their toxicity often the different types of treatment are used in combination, either simultaneously or sequentially. In this thesis, the design, synthesis and biological evaluation of two different kinds of anticancer compounds are described. The synthesis of novel aminobisphosphonates compounds leads to the development of new molecules which induce the immune system, enhancing its antitumor effect. This project is involved in immunotherapy field, a promising and no toxic anticancer therapy approach. Moreover, the synthesis of new natural stilbenes related compounds, involved in the cytotoxic chemotherapy field, lead us to develop a set of high activity molecules, which are promising for further pre-clinical and clinical studies.

    Item Type:Thesis (PhD Thesis)
    Date:23 March 2009
    Tutor:Simoni, Daniele
    Coordinator:Manfredini, Stefano
    Institution:Università degli studi di Ferrara
    PhD:XXI Anno 2006 > SCIENZE FARMACEUTICHE
    Divisions:Dipartimento > Scienze farmaceutiche
    Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
    Uncontrolled Keywords:cancer, immunotherapy, synthesis and biological evaluation
    Deposited on:27 Jul 2009 16:04

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